Laurence A Bindoff Selected Research

sulofenur (ISCU)

6/2015	Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.
2/2012	Antisense oligonucleotide corrects splice abnormality in hereditary myopathy with lactic acidosis.
6/2010	Differences in RNA processing underlie the tissue specific phenotype of ISCU myopathy.

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Laurence A Bindoff Research Topics

Disease

15	Mitochondrial Diseases (Mitochondrial Disease) 12/2021 - 09/2011
6	Epilepsy (Aura) 01/2021 - 12/2012
6	Brain Diseases (Brain Disorder) 01/2017 - 04/2008
4	Status Epilepticus (Complex Partial Status Epilepticus) 11/2021 - 07/2006
4	Muscular Diseases (Myopathy) 01/2021 - 06/2010
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 09/2005
3	Seizures (Absence Seizure) 11/2021 - 02/2014
3	Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia) 01/2020 - 08/2004
3	Liver Failure 01/2019 - 07/2006
3	Parkinson Disease (Parkinson's Disease) 11/2016 - 11/2012
3	MELAS Syndrome (Syndrome, MELAS) 12/2012 - 04/2008
2	Disease Progression 12/2021 - 01/2021
2	Necrosis 11/2021 - 05/2013
2	Lactic Acidosis 01/2021 - 02/2009
2	Hypoxia (Hypoxemia) 03/2020 - 06/2015
2	Stroke (Strokes) 01/2017 - 02/2009
2	Parkinsonian Disorders (Parkinsonism) 04/2016 - 10/2015
2	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 12/2012 - 05/2010
2	Hereditary Myopathy with Lactic Acidosis 02/2012 - 06/2010
2	Ataxia (Dyssynergia) 01/2012 - 09/2005
1	Chronic Renal Insufficiency 03/2022
1	Leigh Disease (Leigh's Disease) 01/2021
1	Rhabdomyolysis 01/2021
1	Carcinogenesis 03/2020
1	Demyelinating Diseases (Demyelinating Disease) 01/2020
1	Epilepsia Partialis Continua 01/2019
1	Inclusion Body Myositis 01/2019
1	Diffuse Cerebral Sclerosis of Schilder (Alpers' Disease) 01/2019
1	Type 2 Diabetes Mellitus (MODY) 01/2019
1	Neoplasms (Cancer) 01/2019
1	Mouth Neoplasms (Oral Cancer) 01/2019
1	Edema (Dropsy) 01/2018
1	Relapsing-Remitting Multiple Sclerosis 01/2017
1	Sideroblastic Anemia 01/2017
1	Gaucher Disease (Gaucher's Disease) 01/2017
1	Multiple Sclerosis 01/2017
1	Premature Aging 11/2016
1	Myalgia 01/2016
1	Limb-girdle muscular dystrophy type 2A 01/2016
1	Muscle Weakness 01/2016
1	Basal Ganglia Diseases (Basal Ganglia Disease) 01/2016
1	Dopa-responsive Dystonia 10/2015
1	Movement Disorders (Movement Disorder) 10/2015
1	autosomal recessive Segawa syndrome 10/2015
1	Pulmonary Hypertension 06/2015
1	Myopia 05/2015
1	Failure to Thrive 04/2014
1	Myoclonic dystonia 02/2014
1	Dystonia (Limb Dystonia) 05/2013
1	Dyskinesias (Dyskinesia) 05/2013

Drug/Important Bio-Agent (IBA)

20	Mitochondrial DNA (mtDNA)IBA 03/2022 - 08/2004
7	DNA Polymerase gammaIBA 01/2021 - 09/2005
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2008
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 09/2011
3	Lactic Acid (Lactate)FDA LinkGeneric 03/2020 - 02/2012
3	Pharmaceutical PreparationsIBA 01/2019 - 09/2010
3	IronIBA 06/2015 - 06/2010
3	sulofenur (ISCU)IBA 06/2015 - 06/2010
3	SulfurIBA 06/2015 - 06/2010
2	fibroblast growth factor 21IBA 01/2021 - 09/2011
2	Metformin (Glucophage)FDA LinkGeneric 01/2021 - 01/2019
2	Adenosine Triphosphate (ATP)IBA 03/2020 - 08/2008
2	Aspartate-tRNA LigaseIBA 01/2016 - 02/2012
2	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2016 - 08/2013
2	EnzymesIBA 02/2012 - 09/2010
2	Valproic Acid (Depakote)FDA LinkGeneric 03/2008 - 07/2006
1	Amyloid (Amyloid Fibrils)IBA 11/2021
1	coenzyme Q10 (CoQ10)IBA 04/2021
1	nicotinamide-beta-ribosideIBA 01/2021
1	Linezolid (Zyvox)FDA Link 01/2021
1	DNA (Deoxyribonucleic Acid)IBA 01/2021
1	N-AcetylcysteinamideIBA 01/2021
1	Mitochondrial Permeability Transition PoreIBA 03/2020
1	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2020
1	CuprizoneIBA 01/2020
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2019
1	Aquaporins (Water Channels)IBA 01/2018
1	ElementsIBA 11/2017
1	Glucosylceramides (Glucocerebrosides)IBA 01/2017
1	Thiamine (Aneurin)FDA Link 01/2016
1	Biotin (Vitamin H)FDA Link 01/2016
1	CalpainIBA 01/2016
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 10/2015
1	CatecholaminesIBA 10/2015
1	Levodopa (L Dopa)FDA LinkGeneric 10/2015
1	MicroRNAs (MicroRNA)IBA 06/2015
1	Carrier Proteins (Binding Protein)IBA 05/2015
1	ProteomeIBA 06/2014
1	Sarcoglycans (beta Sarcoglycan)IBA 02/2014
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 05/2013
1	AntibodiesIBA 05/2013
1	Acetazolamide (Diamox)FDA LinkGeneric 05/2013
1	Racemases and Epimerases (Epimerases and Racemases)IBA 01/2013
1	Coenzyme A (CoA)IBA 01/2013

Therapy/Procedure

3	Therapeutics 01/2021 - 10/2015
1	Euthanasia (Mercy Killing) 11/2021
1	Transcranial Direct Current Stimulation 01/2019
1	General Anesthesia 01/2019
1	Denervation 04/2016
1	Critical Care (Surgical Intensive Care) 04/2014